863127-77-9
- Product Name：dasatinib monohydrate
- Molecular Formula：C22H26Cl N7O2S. H2O
- Purity：99%
- Molecular Weight：506.028
Product Details
Trustworthy Factory Supply 863127-77-9 with Safe Transportation, Buy Quality dasatinib monohydrate
- Molecular Formula:C22H26Cl N7O2S. H2O
- Molecular Weight:506.028
- Melting Point:97-99°C(lit.)
- PSA：143.98000
- Density:1.408 g/cm3
- LogP:3.39810
Dasatinib monohydrate(Cas 863127-77-9) Usage
|
Definition |
ChEBI: A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhyd ous dasatinib (INN). |
|
Biological Activity |
chronic myeloid leukemia (cml) is a disease characterized by the presence of the philadelphia (ph+) chromosome and its oncogenic product, bcr-abl, that is present in >90% of the patients. dasatinib (bms-354825) is a novel, potent, and multitargeted kinase inhibitor that targets abl, src, kit, pdgfr, and other tyrosine kinases. |
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in vitro |
dasatinib is a potent atp-competitive inhibitor in biochemical assays with broad-spectrum antiproliferative activities against hematological and solid tumor cell lines. dasatinib was more potent than imatinib at inhibiting nonmutated bcr-abl kinase activity. in addition, the kinase activity of 14 out of 15 different clinically relevant, imatinib-resistant bcr-abl isoforms was successfully inhibited [1]. |
| Uses | antineoplastic |
InChI:InChI=1/C22H27N7O2S2.H2O/c1-14-4-3-5-16(32)20(14)27-21(31)17-13-23-22(33-17)26-18-12-19(25-15(2)24-18)29-8-6-28(7-9-29)10-11-30;/h3-5,12-13,30,32H,6-11H2,1-2H3,(H,27,31)(H,23,24,25,26);1H2
863127-77-9 Relevant articles
Preparation method for dasatinib monohydrate
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Paragraph 0041; 0072-0073, (2020/07/13)
The invention provides a preparation met...
[...] a novel crystalline form of water composition and its preparation method and pharmaceutical composition
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Paragraph 0081-0104, (2018/04/20)
The invention relates to the technical f...
A convenient new and efficient commercial synthetic route for dasatinib (Sprycel)
Suresh, Garbapu,Nadh, Ratnakaram Venkata,Srinivasu, Navuluri,Yennity, Durgaprasad
, p. 1610 - 1621 (2017/09/08)
A new and efficient synthetic route for ...
POLYMORPHS OF DASATINIB AND PROCESS FOR PREPARATION THEREOF
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Page/Page column 32-33, (2009/05/28)
Provided is dasatinib, solvates thereof ...
863127-77-9 Process route
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- 302962-49-8
dasatanib
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- 863127-77-9
dasatinib monohydrate
| Conditions | Yield |
|---|---|
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With ethanol; water; at 80 ℃; for 2h; Large scale;
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96.44% |
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With water; In ethanol; at 75 - 80 ℃;
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|
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With water; In ethanol; at 0 - 80 ℃; for 5h;
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With water; In methanol; Solvent; Heating;
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21 g |
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- 103-76-4
1-(2-hydroxyethyl)piperazine
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- 302964-08-5
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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- 863127-77-9
dasatinib monohydrate
| Conditions | Yield |
|---|---|
|
1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide; With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 118 ℃; for 4.5h;
With water; In ethanol;
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83.2% |
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1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;
With water; In N,N-dimethyl-formamide; at 20 - 100 ℃; for 2h;
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863127-77-9 Upstream products
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103-76-4
1-(2-hydroxyethyl)piperazine
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302964-08-5
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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302962-49-8
dasatanib
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910297-51-7
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide
863127-77-9 Downstream products
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302962-49-8
dasatanib
Relevant Products
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Dasatinib intCAS：302962-49-8
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3-Amino-4-methylbenzoic acid ethyl esterCAS：41191-92-8
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