391211-97-5
- Product Name：3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid
- Molecular Formula：C13H7F3INO2
- Purity：99%
- Molecular Weight：393.104
Product Details
Chinese Manufacturer Supply Top Purity 99% 3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid 391211-97-5 Customized Supply
- Molecular Formula:C13H7F3INO2
- Molecular Weight:393.104
- Melting Point:189-191°C
- Boiling Point:370.1±42.0 °C(Predicted)
- PKA:3.25±0.36(Predicted)
- PSA：49.33000
- Density:1.939±0.06 g/cm3(Predicted)
- LogP:4.22330
391211-97-5 Relevant articles
Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function
Korkutata, Mustafa,Saitoh, Tsuyoshi,Cherasse, Yoan,Ioka, Shuji,Duo, Feng,Qin, Rujie,Murakoshi, Nobuyuki,Fujii, Shinya,Zhou, Xuzhao,Sugiyama, Fumihiro,Chen, Jiang-Fan,Kumagai, Hidetoshi,Nagase, Hiroshi,Lazarus, Michael
, p. 122 - 132 (2019)
Insomnia is one of the most common sleep...
MODIFIED PROTEINS AND PROTEIN DEGRADERS
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Paragraph 001363-001365, (2021/12/08)
Provided herein are compounds, pharmaceu...
Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
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Page/Page column 94; 96; 99-101, (2021/08/11)
The present disclosure relates to a) cry...
Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
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Page/Page column 21-22, (2021/07/21)
The present disclosure relates to: a) a ...
391211-97-5 Process route
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C20H13F3INO2
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- 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
|
With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; under 1034.32 - 3102.97 Torr; Autoclave;
|
98.8% |
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- 29632-74-4
2-fluro-4-iodoaniline
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- 61079-72-9
2,3,4,-trifluorobenzoic acid
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- 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
|
With lithium amide; In tetrahydrofuran;
|
99% |
|
With lithium amide; In tetrahydrofuran; at 55 ℃; for 2h;
|
92.6% |
|
With lithium amide; In N,N-dimethyl-formamide; Inert atmosphere;
|
85% |
|
With lithium amide; In tetrahydrofuran; at 45 - 55 ℃; for 1.25 - 2.5h; Product distribution / selectivity;
|
80% |
|
2-fluro-4-iodoaniline; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - -67 ℃; for 0.5h;
2,3,4,-trifluorobenzoic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
|
78% |
|
With lithium amide; In acetonitrile; for 0.75h; Product distribution / selectivity; Heating / reflux;
|
72% |
|
With lithium amide; In tetrahydrofuran; at 10 - 50 ℃; for 4h; Temperature; Inert atmosphere; Large scale;
|
56.4% |
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With lithium amide; In tetrahydrofuran; at 200 ℃; for 0.05h; Microwave irradiation;
|
55% |
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With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; for 12h; Cooling with liquid nitrogen;
|
53% |
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With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; Inert atmosphere;
|
53% |
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With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; for 12.5h;
|
53% |
|
|
|
|
With lithium amide; In tetrahydrofuran; water; acetonitrile;
|
391211-97-5 Upstream products
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29632-74-4
2-fluro-4-iodoaniline
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61079-72-9
2,3,4,-trifluorobenzoic acid
391211-97-5 Downstream products
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568599-53-1
methyl 3,4-difluoro-2-(2′-fluoro-4′-iodophenylamino)benzoate
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391212-52-5
N-{[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide
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391210-10-9
PD0325901
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833451-96-0
3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl chloride
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