79456-26-1
- Product Name：3-Chloro-5-(trifluoromethyl)pyridin-2-amine
- Molecular Formula：C6H4ClF3N2
- Purity：99%
- Molecular Weight：196.559
Product Details
Chinese Factory Supply Best Quality 3-Chloro-5-(trifluoromethyl)pyridin-2-amine 79456-26-1 with Efficient Shipping
- Molecular Formula:C6H4ClF3N2
- Molecular Weight:196.559
- Appearance/Colour:Light yellow cryst.
- Vapor Pressure:0.306mmHg at 25°C
- Melting Point:86-90 °C(lit.)
- Refractive Index:1.502
- Boiling Point:201.6 °C at 760 mmHg
- PKA:1.79±0.49(Predicted)
- Flash Point:75.7 °C
- PSA：38.91000
- Density:1.507 g/cm3
- LogP:2.91720
3-Chloro-5-(trifluoromethyl)pyridin-2-amine(Cas 79456-26-1) Usage
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Chemical Properties |
Light yellow Cryst |
|
Uses |
2-?Amino-?3-?chloro-?5-?trifluoromethylpyrid?ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C. |
InChI:InChI=1/C6H4ClF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)
79456-26-1 Relevant articles
Preparation method of 2-amino-3-chloro-5-trifluoromethylpyridine
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Paragraph 0025-0042, (2021/10/27)
The invention relates to the technical f...
Method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine
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Paragraph 0007; 0020; 0023-0025; 0026; 0029-0031; 0032-0037, (2021/02/06)
The invention discloses a method for syn...
Method for preparing 2-amino-3-chloro-5-trifluoromethylpyridine
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Paragraph 0007; 0016; 0018-0019; 0021-0022; 0024-0025; 0027, (2020/09/09)
The invention belongs to the technical f...
CYANOTRIAZOLE COMPOUNDS AND USES THEREOF
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Paragraph 00186, (2020/01/11)
The present invention provides a compoun...
79456-26-1 Process route
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- 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
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- 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
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With ammonia; In water; at 80 ℃; for 9h; under 13501.4 - 16501.7 Torr; Autoclave;
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90% |
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With ammonium hydroxide; at 100 ℃; for 12h; Sealed tube;
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90% |
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With ammonium hydroxide; at 100 - 125 ℃; for 29h; under 1520 Torr;
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82.9% |
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With ammonium hydroxide;
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|
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With ammonia; In tetrahydrofuran; at 100 ℃; for 28h; under 4500.45 - 12001.2 Torr; Pressure; Temperature; Autoclave; Inert atmosphere;
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- 52334-81-3
2-chloro-5-trifluoromethylpyridine
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- 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With 1,3,5-trichloro-2,4,6-triazine; ammonium chloride; copper(l) chloride; In isopropyl alcohol; at 30 ℃; for 6h; Solvent; Reagent/catalyst; Temperature;
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96% |
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Multi-step reaction with 2 steps
1: 39 percent / aq. ammonia / 8 h / 180 °C
2: chlorine, conc.HCl / 50 - 60 °C
With hydrogenchloride; ammonium hydroxide; chlorine;
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|
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Multi-step reaction with 2 steps
1: 75 percent / aq. ammonia / 24 h / 135 °C
2: chlorine, conc.HCl / 50 - 60 °C
With hydrogenchloride; ammonium hydroxide; chlorine;
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79456-26-1 Upstream products
-
74784-70-6
2-amino-5-trifluoromethylpyridine
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69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
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52334-81-3
2-chloro-5-trifluoromethylpyridine
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69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine
79456-26-1 Downstream products
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72537-17-8
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
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178488-36-3
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine
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193979-51-0
[8-Chloro-2-(4-chloro-phenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridin-3-yl]-acetic acid ethyl ester
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303090-94-0
2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol
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