391211-97-5

  • Product Name:3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid
  • Molecular Formula:C13H7F3INO2
  • Purity:99%
  • Molecular Weight:393.104
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Product Details

Chinese Manufacturer Supply Top Purity 99% 3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid 391211-97-5 Customized Supply

  • Molecular Formula:C13H7F3INO2
  • Molecular Weight:393.104
  • Melting Point:189-191°C 
  • Boiling Point:370.1±42.0 °C(Predicted) 
  • PKA:3.25±0.36(Predicted) 
  • PSA:49.33000 
  • Density:1.939±0.06 g/cm3(Predicted) 
  • LogP:4.22330 

391211-97-5 Relevant articles

Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function

Korkutata, Mustafa,Saitoh, Tsuyoshi,Cherasse, Yoan,Ioka, Shuji,Duo, Feng,Qin, Rujie,Murakoshi, Nobuyuki,Fujii, Shinya,Zhou, Xuzhao,Sugiyama, Fumihiro,Chen, Jiang-Fan,Kumagai, Hidetoshi,Nagase, Hiroshi,Lazarus, Michael

, p. 122 - 132 (2019)

Insomnia is one of the most common sleep...

MODIFIED PROTEINS AND PROTEIN DEGRADERS

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Paragraph 001363-001365, (2021/12/08)

Provided herein are compounds, pharmaceu...

Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof

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Page/Page column 94; 96; 99-101, (2021/08/11)

The present disclosure relates to a) cry...

Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof

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Page/Page column 21-22, (2021/07/21)

The present disclosure relates to: a) a ...

391211-97-5 Process route

C<sub>20</sub>H<sub>13</sub>F<sub>3</sub>INO<sub>2</sub>

C20H13F3INO2

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid
391211-97-5

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; under 1034.32 - 3102.97 Torr; Autoclave;
98.8%
2-fluro-4-iodoaniline
29632-74-4

2-fluro-4-iodoaniline

2,3,4,-trifluorobenzoic acid
61079-72-9

2,3,4,-trifluorobenzoic acid

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid
391211-97-5

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

Conditions
Conditions Yield
With lithium amide; In tetrahydrofuran;
99%
With lithium amide; In tetrahydrofuran; at 55 ℃; for 2h;
92.6%
With lithium amide; In N,N-dimethyl-formamide; Inert atmosphere;
85%
With lithium amide; In tetrahydrofuran; at 45 - 55 ℃; for 1.25 - 2.5h; Product distribution / selectivity;
80%
2-fluro-4-iodoaniline; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - -67 ℃; for 0.5h;
2,3,4,-trifluorobenzoic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
78%
With lithium amide; In acetonitrile; for 0.75h; Product distribution / selectivity; Heating / reflux;
72%
With lithium amide; In tetrahydrofuran; at 10 - 50 ℃; for 4h; Temperature; Inert atmosphere; Large scale;
56.4%
With lithium amide; In tetrahydrofuran; at 200 ℃; for 0.05h; Microwave irradiation;
55%
With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; for 12h; Cooling with liquid nitrogen;
53%
With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; Inert atmosphere;
53%
With lithium amide; In tetrahydrofuran; at 0 - 58 ℃; for 12.5h;
53%
 
 
With lithium amide; In tetrahydrofuran; water; acetonitrile;
 

391211-97-5 Upstream products

  • 29632-74-4
    29632-74-4

    2-fluro-4-iodoaniline

  • 61079-72-9
    61079-72-9

    2,3,4,-trifluorobenzoic acid

391211-97-5 Downstream products

  • 568599-53-1
    568599-53-1

    methyl 3,4-difluoro-2-(2′-fluoro-4′-iodophenylamino)benzoate

  • 391212-52-5
    391212-52-5

    N-{[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide

  • 391210-10-9
    391210-10-9

    PD0325901

  • 833451-96-0
    833451-96-0

    3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl chloride

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