284462-37-9
- Product Name：4-(4-Aminophenoxy)-N-methylpicolinamide
- Molecular Formula：C13H13N3O2
- Purity：99%
- Molecular Weight：243.265
Product Details
Reputable Manufacturer Supply Top Purity 99% 4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9 with Cheap Price
- Molecular Formula:C13H13N3O2
- Molecular Weight:243.265
- Vapor Pressure:2.96E-09mmHg at 25°C
- Melting Point:110-112 °C
- Refractive Index:1.618
- Boiling Point:476.8 °C at 760 mmHg
- PKA:13.96±0.46(Predicted)
- Flash Point:242.2 °C
- PSA：77.24000
- Density:1.241 g/cm3
- LogP:2.78780
4-(4-Aminophenoxy)-N-methylpicolinamide(Cas 284462-37-9) Usage
|
Chemical Properties |
Light-Brown Solid |
|
Uses |
Sorafenib intermediate |
InChI:InChI=1/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)
284462-37-9 Relevant articles
LEADOPT: An automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors
Li, Guo-Bo,Ji, Sen,Yang, Ling-Ling,Zhang, Rong-Jie,Chen, Kai,Zhong, Lei,Ma, Shuang,Yang, Sheng-Yong
, p. 523 - 538 (2015)
Lead optimization is one of the key step...
Synthesis and biological evaluation of novel 4-(4-formamidophenylamino)-N-methylpicolinamide derivatives as potential antitumor agents
Hu, Min,Meng, Nana,Xia, Yong,Xu, Youzhi,Yu, Luoting,Zeng, Xiuxiu,Zhou, Shuyan
, (2021/06/11)
A novel series of 4-(4-formamidophenylam...
Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity against VEGFR2, p38α, and B-Raf
Cheung, Mui,Desai, Tina A.,Fries, Harvey,Gatto, Gregory J.,Graves, Alan P.,Holt, Dennis A.,Kallander, Lara S.,Patterson, Jaclyn R.,Shewchuk, Lisa,Stoy, Patrick,Totoritis, Rachel,Wang, Liping
, p. 15651 - 15670 (2021/11/16)
A series of diarylurea inhibitors of the...
Sorafenib sulfydryl derivative and application thereof
-
Paragraph 0019-0021, (2021/04/10)
The invention belongs to the field of me...
Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-κB and TAK1 activities: Cheminformatics tools RDKit applied in drug design
Tan, Ninghua,Wang, Linxiao,Wang, Zhe,Zhang, Qian,Zhu, Wufu
, (2021/07/09)
Using cheminformatics tools RDKit and li...
284462-37-9 Process route
-
- 864272-34-4
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
-
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
|
With hydrogen; nickel; In tetrahydrofuran; methanol; at 20 ℃; Product distribution / selectivity;
|
97% |
|
With palladium 10% on activated carbon; hydrogen; In methanol; at 35 ℃; for 2h; under 2068.65 Torr;
|
95% |
|
With palladium 10% on activated carbon; hydrogen; In methanol; at 40 - 50 ℃; under 7500.75 Torr; Solvent; Autoclave;
|
92.5% |
|
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine; With iron(III) chloride hexahydrate; pyrographite; In ethanol; at 90 ℃; for 0.5h; Sonication;
With hydrazine hydrate; In ethanol; Sonication;
|
70% |
|
With ammonia; tetra(n-butyl)ammonium hydrogensulfate; iron;
|
20.1 g |
-
- 73771-11-6
4-chloro-pyridine-2-carboxylic acid hydrazide
-
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
|
With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
4-chloro-pyridine-2-carboxylic acid hydrazide; With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 6h; Inert atmosphere;
|
80% |
284462-37-9 Upstream products
-
123-30-8
4-amino-phenol
-
220000-87-3
4-chloro-N-methylpicolinamide
-
864272-34-4
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
-
284462-78-8
4-(3-aminophenoxy)-N-methylpicolinamide
284462-37-9 Downstream products
-
952287-48-8
4-BOC-amino-phenoxy-pyridine-2-carboxylic acid methylamide
-
284461-73-0
sorafenib
-
864272-27-5
C13H14N4O2
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