917392-54-2
- Product Name：4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester
- Molecular Formula：C18H16 N4 O2
- Purity：99%
- Molecular Weight：320.351
Product Details
Chinese Factory Supply Buy Quality 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester 917392-54-2 with Fast Shipping
- Molecular Formula:C18H16 N4 O2
- Molecular Weight:320.351
- Vapor Pressure:0mmHg at 25°C
- Melting Point:148 - 150°C
- Boiling Point:538.59oC at 760 mmHg
- PKA:2.70±0.12(Predicted)
- Flash Point:279.53oC
- PSA：77.00000
- Density:1.258
- LogP:3.45020
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester(Cas 917392-54-2) Usage
|
Uses |
Methyl 4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate is an intermediate used in the synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide (M326838), which is an impurity of Nilotinib (N465300), a possible agent in the treatment of chronic myelogenous leukemia. |
InChI:InChI=1/C18H16N4O2/c1-12-5-6-13(17(23)24-2)10-16(12)22-18-20-9-7-15(21-18)14-4-3-8-19-11-14/h3-11H,1-2H3,(H,20,21,22)
917392-54-2 Relevant articles
SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE
-
, (2021/04/23)
Processes and useful intermediates for t...
MANUFACTURING METHOD OF BENZOIC ACID COMPOUND
-
Paragraph 0073-0077, (2020/02/18)
PROBLEM TO BE SOLVED: To provide a simpl...
DEUTERATED AMINOPYRIDINE COMPOUNDS
-
Paragraph 00106, (2018/06/30)
The present disclosure is directed to Co...
Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib
Li, Yong-Tao,Wang, Jing-Han,Pan, Cheng-Wen,Meng, Fan-Fei,Chu, Xiao-Qian,Ding, Ya-Hui,Qu, Wen-Zheng,Li, Hui-Ying,Yang, Cheng,Zhang, Quan,Bai, Cui-Gai,Chen, Yue
, p. 1419 - 1427 (2016/02/19)
Three novel series of 1,2,3-triazole and...
917392-54-2 Process route
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- 1025716-98-6
3-guanidino-4-methylbenzoic acid methyl ester
-
- 55314-16-4,75415-01-9,123367-26-0
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
-
![4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid](/upload/2024/4/26f8b0da-8098-4147-9478-63c15b30154b.png)
- 641569-94-0
4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
-
![methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate](/upload/2024/4/cef1d5be-96d1-41e2-b8cf-cf2eacbdfb18.png)
- 917392-54-2
methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
| Conditions | Yield |
|---|---|
|
3-guanidino-4-methylbenzoic acid methyl ester; 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one; With sodium hydroxide; ethanol; for 16h; Heating / reflux;
With hydrogenchloride; water; pH=~ 3 - 4;
|
-
- 104901-43-1
methyl 3-bromo-4-methylbenzoate
-
- 66521-66-2
4-pyridin-3-ylpyrimidin-2-ylamine
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- 917392-54-2
methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
| Conditions | Yield |
|---|---|
|
With C43H63ClNO2PPd; caesium carbonate; In 1,4-dioxane; at 120 ℃; for 1.5h; Inert atmosphere;
|
95% |
|
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; In 1,4-dioxane; at 120 ℃; for 1.5h; Inert atmosphere;
|
81% |
917392-54-2 Upstream products
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1025716-99-7
3-[(aminoiminomethyl)amino]-4-methylbenzoic acid methylester mononitrate
-
55314-16-4
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
-
55314-16-4
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
-
1025716-98-6
3-guanidino-4-methylbenzoic acid methyl ester
917392-54-2 Downstream products
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641571-10-0
nilotinib
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641569-94-0
4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
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1205540-16-4
N-(3-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
-
1186619-20-4
4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid N'-4-[[(4-methyl-1-piperazinyl)methyl]benzoyl]hydrazide
Relevant Products
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Nilotinib intCAS：641571-10-0
-
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneCAS：55314-16-4
-
Methyl 3-amino-4-methylbenzoateCAS：18595-18-1