55314-16-4

  • Product Name：1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
  • Molecular Formula：C10H12N2O
  • Purity：99%
  • Molecular Weight：176.218
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Product Details

Quality Manufacturer Supply High Purity 99% 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4 with Efficient Delivery

  • Molecular Formula:C10H12N2O
  • Molecular Weight:176.218
  • Appearance/Colour:Off-White Solid 
  • Vapor Pressure:0.00356mmHg at 25°C 
  • Melting Point:86-88 °C 
  • Refractive Index:1.545 
  • Boiling Point:281.442 °C at 760 mmHg 
  • PKA:6.19±0.70(Predicted) 
  • Flash Point:124.012 °C 
  • PSA：33.20000 
  • Density:1.071 g/cm3 
  • LogP:1.33960 

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one(Cas 55314-16-4) Usage

Chemical Properties

Off-White Solid

Uses

Rasagiline intermediate

InChI:InChI=1/C10H12N2O/c1-12(2)8-5-10(13)9-3-6-11-7-4-9/h3-8H,1-2H3/b8-5+

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55314-16-4 Process route

methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

<i>N</i>,<i>N</i>-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4,75415-01-9,123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Conditions
Conditions Yield
In neat (no solvent); at 65 - 100 ℃;
96%
at 85 ℃; for 10h; Large scale;
95%
In 5,5-dimethyl-1,3-cyclohexadiene; for 20h; Reflux;
94%
In para-xylene; Reflux;
94%
at 100 ℃; for 16h; Inert atmosphere;
92.6%
With acetic acid; at 90 - 95 ℃; for 2h; Product distribution / selectivity;
92%
In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 20h; Inert atmosphere; Schlenk technique;
92.6%
In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃;
92%
In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 20h;
90%
In o-xylene; at 130 ℃; for 20h;
90%
In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;
87%
Reflux;
85%
In neat (no solvent); for 23h; Reflux;
85%
In 5,5-dimethyl-1,3-cyclohexadiene; for 21h; Reflux;
83.3%
for 4h; Reflux; Neat (no solvent);
82%
Reflux;
82%
In ethanol; at 20 ℃; for 12h; Reflux;
72%
In ethanol; for 12h; Reflux;
70%
In ethanol; for 12h; Inert atmosphere; Reflux;
70%
In methanol; for 10h; Reflux;
60%
In ethanol; at 80 ℃; for 16 - 18h; Heating / reflux;
50.8%
In ethanol; Heating;
 
methyl-3-pyridylketone; N,N-dimethyl-formamide dimethyl acetal; for 23h; Heating / reflux;
at 0 ℃;
 
In ethanol; Reflux; Inert atmosphere;
 
In toluene; for 24h; Reflux;
 
Reflux;
 
for 6h; Reflux;
 
In toluene; for 18h; Inert atmosphere; Reflux;
 
Reflux;
 
at 100 ℃; for 12h; Inert atmosphere; neat (no solvent);
 
at 25 - 80 ℃; for 2h; Inert atmosphere;
60.2 g
In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Reflux;
 
at 170 ℃; for 0.05h; Sealed tube;
 
In 5,5-dimethyl-1,3-cyclohexadiene; for 48h; Reflux;
 
In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;
 
In toluene; at 120 ℃; for 0.25h; Microwave irradiation;
 
at 110 ℃;
 
for 16h; Heating / reflux;
 
for 16h; Heating / reflux;
 
for 16h; Heating / reflux;
 
for 24h; Reflux;
6.9 g
at 82 - 84 ℃; for 8h;
 
at 103 ℃;
 
methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

formic acid ethyl ester
109-94-4

formic acid ethyl ester

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4,75415-01-9,123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Conditions
Conditions Yield
With sodium; acetic acid; dimethyl amine; In methanol; hexane; toluene;
 

55314-16-4 Upstream products

  • 350-03-8
    350-03-8

    methyl-3-pyridylketone

  • 4637-24-5
    4637-24-5

    N,N-dimethyl-formamide dimethyl acetal

  • 109-94-4
    109-94-4

    formic acid ethyl ester

  • 1188-33-6
    1188-33-6

    N,N-dimethylformamide diethyl diacetal

55314-16-4 Downstream products

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    152460-09-8

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    152459-95-5

    imatinib

  • 66521-66-2
    66521-66-2

    4-pyridin-3-ylpyrimidin-2-ylamine

  • 152460-10-1
    152460-10-1

    6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

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