72537-17-8
- Product Name：3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine
- Molecular Formula：C6H2ClF4N
- Purity：99%
- Molecular Weight：199.535
Product Details
Reputable Factory Supply High Purity 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine 72537-17-8 with Efficient Transportation
- Molecular Formula:C6H2ClF4N
- Molecular Weight:199.535
- Vapor Pressure:3.944mmHg at 25°C
- Melting Point:16-20 °C(lit.)
- Refractive Index:n20/D 1.433(lit.)
- Boiling Point:155.197 °C at 760 mmHg
- Flash Point:47.662 °C
- PSA：12.89000
- Density:1.508 g/cm3
- LogP:2.89290
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE(Cas 72537-17-8) Usage
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General Description |
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine. |
InChI:InChI=1/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
72537-17-8 Relevant articles
Bitopertin synthetic method and intermediate
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Paragraph 0061-0063, (2018/03/26)
The present invention discloses a new sy...
Preparation method of 2-fluorine-3-chlorine-5-trifluoromethylpyridine
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Paragraph 0026; 0027; 0028; 0033; 0036, (2018/07/30)
The invention relates to the technical f...
A 2 - cyano - 3 - chloro - 5 - trifluoro methyl pyridine synthesis method (by machine translation)
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Paragraph 0032; 0033, (2017/11/04)
The invention discloses a 2 - cyano - 3 ...
72537-17-8 Process route
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- 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine
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- 72537-17-8
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With pyridine hydrogenfluoride; sodium nitrite; 1.) O deg C, 20 min, 2.) 20 deg C, 1 h;
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99% |
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With pyridine; hydrogen fluoride; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 30 min; 2.) 20 deg C, 1 h;
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-
- 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
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- 72537-17-8
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With potassium carbonate; cesium fluoride; In dimethyl sulfoxide; at 120 ℃; for 4h; under 18.7519 - 22.5023 Torr; Product distribution / selectivity;
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100% |
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With potassium carbonate; cesium fluoride; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 1 - 3h; Product distribution / selectivity;
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98% |
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With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride; In N,N-dimethyl acetamide; at 170 ℃; for 5h; Temperature;
|
97% |
|
With potassium fluoride; In dimethyl sulfoxide; at 115 - 120 ℃; Concentration; Solvent; Inert atmosphere;
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93.6% |
|
With potassium fluoride; In dimethyl sulfoxide; at 110 - 120 ℃; for 2h;
|
92% |
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With potassium carbonate; cesium fluoride; In dimethyl sulfoxide; at 120 ℃; for 4h; Inert atmosphere;
|
89.2% |
72537-17-8 Upstream products
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79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine
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69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
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69045-83-6
2,3-dichloro-5-(trichloromethyl)pyridine
72537-17-8 Downstream products
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451456-58-9
1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone
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69045-89-2
2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine
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451456-48-7
3-chloro-2-[4-(prop-2-enyloxy)phenoxy]-5-(trifluoromethyl)pyridine
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451456-45-4
4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(hydroxymethyl)phenol
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Gefitinib intCAS：184475-35-2
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