22245-83-6
- Product Name：2-hydroxy-3-trifluoromethylpyridine
- Molecular Formula：C6H4F3NO
- Purity：99%
- Molecular Weight：163.099
Product Details
Chinese Factory Supply Reliable Quality 2-hydroxy-3-trifluoromethylpyridine 22245-83-6 with Efficient Shipping
- Molecular Formula:C6H4F3NO
- Molecular Weight:163.099
- Vapor Pressure:0.0947mmHg at 25°C
- Melting Point:150-153 ºC
- Refractive Index:1.436
- Boiling Point:223.7 ºC at 760 mmHg
- PKA:9.67±0.10(Predicted)
- Flash Point:89.1 ºC
- PSA：33.12000
- Density:1.398 g/cm3
- LogP:1.80600
2-Hydroxy-3-trifluoromethylpyridine(Cas 22245-83-6) Usage
|
Chemical Properties |
White powder |
|
Uses |
2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist . |
InChI:InChI=1/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
22245-83-6 Relevant articles
Deoxofluorination of (Hetero)aromatic Acids
Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.
, p. 3110 - 3124 (2020/03/23)
Diverse trifluoromethyl-substituted comp...
Preparation method of 2-hydroxyl-3-trifluoromethylpyridine
-
, (2018/06/21)
The invention relates to the technical f...
ANDROGEN RECEPTOR MODULATOR FOR TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
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Paragraph 0055-0056, (2016/11/14)
PROBLEM TO BE SOLVED: To provide a serie...
Substituted diazaspiroalkanes as androgen receptor modulators
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Page/Page column 14; 15, (2016/08/10)
This invention provides for compounds of...
22245-83-6 Process route
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- 142-08-5
2-hydroxypyridin
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- 2314-97-8,263005-66-9
iodotrifluoromethane
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- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
|
With ferrocene; dihydrogen peroxide; dimethyl sulfoxide; In water; at 40 - 50 ℃; for 0.333333h;
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50% |
|
With ferrocene; dihydrogen peroxide; In water; dimethyl sulfoxide;
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68 %Spectr. |
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- 65753-47-1
2-chloro-3-trifluoromethyl-pyridine
-
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
|
With potassium hydroxide; In tert-butyl alcohol; for 10h; Heating;
|
73% |
|
2-chloro-3-trifluoromethyl-pyridine; With potassium hydroxide; In tert-butyl alcohol; at 20 - 90 ℃;
With acetic acid; In tert-butyl alcohol;
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|
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Multi-step reaction with 3 steps
1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave
2: ammonia / water / 10 h / 130 °C / 22502.3 Torr
3: sodium nitrite; hydrogenchloride / water / 3 h / 0 °C
With hydrogenchloride; hydrogen fluoride; ammonia; sodium nitrite; In water;
|
22245-83-6 Upstream products
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183610-70-0
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65753-47-1
2-chloro-3-trifluoromethyl-pyridine
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609-71-2
1,2-dihydro-2-oxonicotinic acid
-
142-08-5
2-hydroxypyridin
22245-83-6 Downstream products
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104040-74-6
3-trifluoromethylpyridine-2(1H)-thione
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76041-79-7
5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one
-
211122-40-6
5-bromo-2-chloro-3-(trifluoromethyl)pyridine
-
1403387-89-2
5-bromo-2-(neopentyloxy)-3-(trifluoromethyl)pyridine
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