835621-07-3
- Product Name：Regorafenib (Hydrochloride) int
- Molecular Formula：C21H15ClF4N4O3.ClH
- Purity：99%
- Molecular Weight：519.283
Product Details
Factory Supply Buy High Grade Regorafenib (Hydrochloride) int 835621-07-3 with Fast Delivery
- Molecular Formula:C21H15ClF4N4O3.ClH
- Molecular Weight:519.283
- Appearance/Colour:White to off-white solid
- PSA：95.84000
- LogP:6.96830
835621-07-3 Relevant articles
Preparation process of agomelatin intermediate
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Paragraph 0060-0062; 0064, (2019/08/21)
The invention belongs to the field of me...
SYNTHETIC METABOLITES OF FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR THE TREATMENT AND PREVENTION DISEASES AND CONDITIONS
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, (2011/11/01)
Synthetic metabolites of compounds of Fo...
TREATMENT OF CANCERS HAVING RESISTANCE TO CHEMOTHERAPEUTIC AGENTS
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Page/Page column 17-18, (2008/12/07)
The present invention provides compositi...
TREATMENT OF CANCERS WITH ACQUIRED RESISTANCE TO KIT INHIBITORS
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Page/Page column 15, (2008/12/07)
The present invention provides compositi...
835621-07-3 Process route
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- 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
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C7H3ClF3NO
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![4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride](/upload/2024/4/e0f4b09e-a099-424e-8fdd-450162c671e3.png)
- 835621-07-3
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride
Conditions
| Conditions | Yield |
|---|---|
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In tetrahydrofuran; at 25 ℃; for 3.41667h; Inert atmosphere;
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- 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
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- 835621-07-3
4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: toluene / 72 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran
With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; toluene;
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835621-07-3 Upstream products
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755037-03-7
regorafenib
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399-95-1
4-amino-3-fluorophenol
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757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
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394-41-2
3-fluoro-4-nitrophenol
Relevant Products
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Regorafenib intCAS：755037-03-7
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Regorafenib monohydrate intCAS：1019206-88-2