3934-20-1
- Product Name：2,4-Dichloropyrimidine
- Molecular Formula：C4H2Cl2N2
- Purity：99%
- Molecular Weight：148.979
Product Details
Trustworthy Manufacturer Supply Best Quality 2,4-Dichloropyrimidine 3934-20-1 with Low Price
- Molecular Formula:C4H2Cl2N2
- Molecular Weight:148.979
- Appearance/Colour:White solid
- Vapor Pressure:0.298mmHg at 25°C
- Melting Point:57-61 °C(lit.)
- Refractive Index:1.559
- Boiling Point:209.1 °C at 760 mmHg
- PKA:-2.84±0.20(Predicted)
- Flash Point:104.3 °C
- PSA：25.78000
- Density:1.493 g/cm3
- LogP:1.78340
2,4-Dichloropyrimidine(Cas 3934-20-1) Usage
|
Chemical Properties |
White Solid |
|
Uses |
2,4-Dichloropyrimidine was used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles. |
|
General Description |
2,4-Dichloropyrimidine is a human skin sensitizer. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines. |
InChI:InChI=1/C4H2Cl2N2/c5-3-1-2-7-4(6)8-3/h1-2H
3934-20-1 Relevant articles
Preparation and characterization of bis[4-dimethylamino-2-pyrimidyl] dichalcogenides (S, Se, Te): X-ray crystal structure of bis[4-dimethylamino-2-pyrimidyl] diselenide and its physicochemical behavior in microemulsion media
Bhasin,Arora, Ekta,Kaur, Khushwinder,Kang, Sung-Kyu,Gobel, Michael,Klapoetke,Mehta
, p. 247 - 252 (2009)
Novel and synthetically important bis[4-...
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease
Manzoor, Shoaib,Gabr, Moustafa T.,Rasool, Bisma,Pal, Kavita,Hoda, Nasimul
, (2021/09/28)
Development of multitargeted ligands hav...
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies
Hoda, Nasimul,Manzoor, Shoaib,Petreni, Andrea,Raza, Md Kausar,Supuran, Claudiu T.
supporting information, (2021/07/16)
A series of new triazole-sulfonamide bea...
Deaminative chlorination of aminoheterocycles
Cornella, Josep,Faber, Teresa,Gómez-Palomino, Alejandro,Ghiazza, Clément
, (2021/12/23)
Selective modification of heteroatom-con...
Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis
Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua
supporting information, p. 146 - 153 (2020/03/10)
The chlorination of hydroxy aza-arenes w...
3934-20-1 Process route
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- 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil
-
- 3934-20-1
2,6-Dichloropyrimidine
Conditions
| Conditions | Yield |
|---|---|
|
With trichlorophosphate; at 105 ℃;
|
98% |
|
With phosgene; Triphenylphosphine oxide; In nitrobenzene; at -5 - 105 ℃; for 0.666667h; Inert atmosphere;
|
90% |
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With trichlorophosphate; at 105 ℃; for 5h;
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90% |
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With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 0 - 95 ℃; for 3h; Sealed tube;
|
82% |
|
With trichlorophosphate; at 110 ℃; for 3.5h; Inert atmosphere;
|
72.3% |
|
With tetraethylammonium chloride; trichlorophosphate; at 120 ℃; for 1h;
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36% |
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With trichlorophosphate; at 140 ℃; im Rohr;
|
|
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With N,N-dimethyl-aniline; trichlorophosphate; at 200 ℃;
|
|
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With trichlorophosphate; at 120 ℃;
|
|
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With phosphorus pentachloride; trichlorophosphate; at 140 ℃;
|
|
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With trichlorophosphate;
|
|
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With N,N-dimethyl-aniline; trichlorophosphate; Heating;
|
|
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With trichlorophosphate; at 110 ℃; for 3.5h;
|
|
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With N,N-dimethyl-aniline; trichlorophosphate; at 0 ℃; for 4h; Reflux;
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|
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With N,N-dimethyl-aniline; trichlorophosphate; at 0 ℃; for 4h; Reflux;
|
80 g |
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With ((1,3,5-triazine-2,4,6-triyl)tris(oxy))tris(triphenylphosphonium) chloride; In neat (no solvent); at 140 - 150 ℃; for 2h;
|
|
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With N,N-dimethyl-aniline; trichlorophosphate; at 0 ℃; for 4h; Reflux;
|
80 g |
|
With N,N-dimethyl-aniline; trichlorophosphate; at 0 ℃; for 4h; Reflux;
|
80 g |
|
With trichlorophosphate; at 105 ℃;
|
-
- 66-22-8,51953-14-1
2,4-dihydroxypyrimidine
-
- 3934-20-1
2,6-Dichloropyrimidine
Conditions
| Conditions | Yield |
|---|---|
|
With dmap; thionyl chloride; bis(trichloromethyl) carbonate; at 65 - 70 ℃;
|
95% |
|
With dmap; thionyl chloride; bis(trichloromethyl) carbonate; for 9.5h; Reflux; Green chemistry;
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95% |
|
With pyridine; trichlorophosphate; at 180 ℃; for 2h; under 150.015 - 900.09 Torr; Neat (no solvent);
|
91% |
|
With trichlorophosphate;
|
|
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With thionyl chloride; at 20 ℃;
|
3934-20-1 Upstream products
-
141-90-2
4-hydroxy-2-mercaptopyrimidine
-
15493-07-9
dichlorotriphenoxyphosphorane
-
66-22-8
uracil
-
3764-01-0
2,4,6-trichloropyrimidine
3934-20-1 Downstream products
-
22536-63-6
2-chloro-4-methoxypyrimidine
-
20461-60-3
2,4-diethoxypyrimidine
-
62880-79-9
2,4-bis-ethylmercapto-pyrimidine
-
854476-92-9
2-chloro-pyrimidin-4-yl thiocyanate
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