641569-94-0
- Product Name：4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
- Molecular Formula：C17H14N4O2
- Purity：99%
- Molecular Weight：306.324
Product Details
Factory Supply Buy High Quality 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0 with Safe Shipping
- Molecular Formula:C17H14N4O2
- Molecular Weight:306.324
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.676
- Boiling Point:587.927 °C at 760 mmHg
- PKA:4.35±0.10(Predicted)
- Flash Point:309.367 °C
- PSA：88.00000
- Density:1.336 g/cm3
- LogP:3.36180
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(Cas 641569-94-0) Usage
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Uses |
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia. |
InChI:InChI=1/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
641569-94-0 Relevant articles
SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE
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Page/Page column 35, (2021/04/23)
Processes and useful intermediates for t...
Method for preparing N-(5-carboxyl-2-methylphenyl)-4-(3-pyridine)-2-pyrilamine
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Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- And BCRP-Mediated Multidrug Resistance
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, (2020/02/18)
PROBLEM TO BE SOLVED: To provide a simpl...
641569-94-0 Process route
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butyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
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![4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid](/upload/2024/4/e3d63561-f1d0-4b7a-8e91-2bd04cf853ea.png)
- 641569-94-0
4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
| Conditions | Yield |
|---|---|
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With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 12h;
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90% |
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4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzonitrile
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- 641569-94-0
4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
| Conditions | Yield |
|---|---|
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With water; sodium hydroxide; In ethanol; at 100 ℃; for 5h;
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92% |
641569-94-0 Upstream products
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641569-97-3
4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester
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917392-54-2
methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
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1025716-98-6
3-guanidino-4-methylbenzoic acid methyl ester
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55314-16-4
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
641569-94-0 Downstream products
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1025717-56-9
3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-6-yl)-4-methylbenzamide trifluoroacetate
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1079904-27-0
[2-methyl-5-(6-trifluoromethyl-1H-benzoimidazol-2-yl)-phenyl]-(4-pyridin-3-yl-pyrimidin-2-yl)-amine
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1089725-66-5
C34H35F3N6O5
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1205540-17-5
4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride
Relevant Products
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Nilotinib intCAS：641571-10-0
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