606143-52-6
- Product Name：Selumetinib
- Molecular Formula：C17H15BrClFN4O3
- Purity：99%
- Molecular Weight：457.687
Product Details
Quality Manufacturer Supply Buy High Grade Selumetinib 606143-52-6 with Reasonable Price
- Molecular Formula:C17H15BrClFN4O3
- Molecular Weight:457.687
- Appearance/Colour:White or pale white solid.
- PKA:14.20±0.10(Predicted)
- PSA：88.41000
- Density:1.692 g/cm3
- LogP:3.98950
606143-52-6 Relevant articles
Method for preparing semetinib
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Paragraph 0057-0063, (2021/04/21)
The invention relates to a method for pr...
Synthesis method of semetinib
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Paragraph 0056-0062, (2021/05/08)
The invention relates to a synthesis met...
INTERMEDIATES OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MAP2K OR MEK) INHIBITORS AND PROCESS FOR THEIR PREPARATION
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Page/Page column 12, (2018/04/21)
The present invention relates to interme...
NOVEL HYDROGEN SULFATE SALT
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Page/Page column 21-22, (2008/06/13)
The present invention relates to Compoun...
606143-52-6 Process route
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![5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide](/upload/2024/4/ce0ba9d2-a26f-439c-90e4-2842e186ff64.png)
- 606144-05-2
5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide
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- 606143-52-6
selumetinib
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; water; In ethanol; for 24h;
|
100% |
|
With hydrogenchloride; water; In ethanol; for 24h;
|
100% |
|
With hydrogenchloride; In ethanol; water; at 25 - 30 ℃; for 24h;
|
70% |
-
![5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid](/upload/2024/4/8ec39be8-6636-47f7-8507-c0801b3e52e1.png)
- 606144-04-1
5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid
-
- 3279-95-6
O-(2-hydroxyethyl)hydroxylamine
-
- 606143-52-6
selumetinib
| Conditions | Yield |
|---|---|
|
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Temperature;
|
91.5% |
|
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
|
91.5% |
606143-52-6 Upstream products
-
606144-05-2
5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide
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1000340-06-6
methyl 5-[(4-bromophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate
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606144-02-9
methyl 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate
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606093-58-7
4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester
606143-52-6 Downstream products
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942275-12-9
6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide p-toluenesulfonate
-
943332-08-9
6-(4-bromo-2-chlorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)amide hydrogen sulphate
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1450912-89-6
C24H26BrClF3N7O3
-
1535208-24-2
6-(4-bromo-2-chloroanilino)-7-fluoro-N-[2-(α-D-glucopyranosyloxy)ethoxy]-3-methylbenzimidazole-5-carboxamide
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